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In cells exposed to high levels of oxidative stress, like red blood cells (RBC), up to 10% of the glucose consumption may be directed to the pentose phosphate pathway (PPP) for the production of the NADPH needed for this reaction

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-lipoic acid is a trap for hydrogen peroxide and hypochlorite, and dihydrolipoic acid is for superoxide radical [6]

One hypothesis proposes that muscle insulin resistance results from decreased mitochondrial fatty acids oxidation