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However, as explained by the Alzheimers Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesnt necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind
We see this play out constantly in our clinic
Those with digestive issues such as IBS, IBD, Crohns, or coeliac disease may struggle to absorb the vital nutrient
Formulation matters a lot: Copper peptides become inactive in the presence of strong chelating agents or low-pH acids
The inclusion of B12 aims to boost energy levels and support metabolic processes
Available from: Deniau AL, Mosset P, Pedrono F, Mitre R, Le Bot D, Legrand AB
