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The National Institute on Drug Abuse (NIDA) warns that individuals recovering from opioid addiction are at risk of relapse if exposed to these opioid-acetaminophen combinations

However, based on research, whats often suggested is a daily dose between 3 and 5 g (the amount shown to improve sleep quality in a 2024 study)

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10.1073/pnas.0610031104 83 NavratilA