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Heres what the clinical evidence shows for FDA-approved medications: Semaglutide ( Wegovy ): In the STEP 1 trial, participants on weekly 2.4 mg semaglutide lost an average of about 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group

doi: 10.1371/journal.pone.0148640 116 SeminiGPaapeDBlumeMSerneeMFPeres-AlonsoDCalvignac-SpencerSet al