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GCGR activation, represented in green, is unique in that glucagon receptors are robustly expressed on hepatocytes, enabling direct liver-directed metabolic effects - a mechanistic feature absent from both GLP-1R and GIPR signaling

Pelletier AM, Thomas J, Shaw F

The symptom improvement from this study is encouraging, but one study detail shouldnt be overlooked: 26 people began the ketogenic diet, but only 20 stuck with it through the trial

One participant with a placebo developed severe hypoglycemia due to CGM malfunction

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However, a recently published case report demonstrated semaglutide-induced lupus erythematosus with multiple organ involvement [289]