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In addition to activating NRF2 by modifying Kelch-like ECH-associated protein 1 (KEAP1) thiols (Cys151), MMF also exerts undesirable off-target actions by indiscriminately modifying other protein thiols as well 3,4,5,6,7,8
Thus, Glutathione, being the master antioxidant, has many important functions as mentioned below- Neutralizes free radicals and reactive oxygen species (ROS) directly
Therefore, -EC is expected to contribute to prevention and improvement of age-related disorders and chronic diseases, in particular for neurodegenerative diseases by increasing intracellular GSH level
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Indeed, in addition to glycolysis, cancer cells can carry out various metabolic strategies such as fatty acid oxidation (FAO) 2,5
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