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According to WebMD, The more common B12 injection side effects are: Swelling at the injection site Mild dirhhea Itching Swelling in the body Low potassium (weakness, irregular heartbeat) There is a case report of an anaphylactic reaction to a B12 injection in a 55 year old women receiving cyanocobalamin, but these reactions are thought to be rare

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When starting Vitamin B12 therapy, its not unusual for individuals to grapple with questions like, Feeling worse after my B12 injection, is that natural? This period, often termed as a healing crisis, can manifest through symptoms such as: Enhanced feelings of fatigue, tiredness, and increased sleep requirements Sensations akin to mild flu-like symptoms or body aches Experiences of headaches, nausea, or feelings of being lightheaded A foggy mind and challenges with concentration Mood fluctuations including irritability, anxiety, or a subdued mood Alterations in appetite and digestive patterns Contrary to being seen as an adverse reaction, these symptoms are essentially indicative of the body acknowledging and adapting to the surge of B12

As we age, levels can fall