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Its sleep benefit comes from restoring the pineal glands melatonin output capacity, which declines significantly with age
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The methyl donor for this reaction is S-adenosylmethionine (SAM or AdoMet) and the reaction is catalyzed by the enzyme guanidinoacetate N -methyltransferase
But why, I ask, are there no gold-standard trials on humans
Not to forget its implications in brain health, skin health, and liver function
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