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Clinical Results with Combination Therapy The SURPASS-COMBO trial demonstrated remarkable outcomes with CagriSema

6 Conclusion and perspective Although MSTN is well known for its role as a key protein that regulates muscle homeostasis and prevents excessive muscle growth, its role in regulating metabolic processes, especially in metabolic syndrome, is also attracting increasing attention

Reasonable confounding factors did not significantly affect the validity of the results, leading to a high quality of evidence rating for these outcomes (Table 4)

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not examined

Radioimmunological determination of urinary melatonin in humans: correlation with plasma levels and typical 24-hour rhythmicity