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As an antioxidant enzyme with high expression in epididymal tissues, GPX5 plays an important role in maintaining the microenvironment of the epididymis, protecting sperm from oxidative stress, and maintaining the integrity of DNA structure

The table below shows how all three compare

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Modules correlated with the KO genotype were enriched for neuronal and synaptic genes involved in vesicle-mediated transport, neurotransmitter secretion, and GTPase activity, suggesting that RAMP deletion disrupts synaptic signaling networks critical for metabolic regulation [2]

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Activating the focal adhesion kinase (FAK)-paxillin pathway strengthens cellular adhesion, migration, and survival while supporting matrix remodeling and cartilage integrity