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This dosage is higher than the recommended daily amount in order to help increase low levels to sufficient and reduce how long recovery from B12 deficiency can take

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While that gap is meaningful, it was not dramatic enough for AOD-9604 to win approval as a standalone obesity drug, and formal development was paused in 2007

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(2016) Effect of Vitamin B12 supplementation on serum homocysteine in patients undergoing hemodialysis: A randomized controlled trial