In the gastrointestinal tract, COX-1-derived prostaglandins function to increase production of the thick mucus/bicarbonate layer that coats gastric surfaces and buffers them against stomach acid (Vonkeman 2010)
(4) Warnings and Precautions Diabetic Ketoacidosis in Patients with Type 1 Diabetes Mellitus and Other Ketoacidosis: Consider ketone monitoring in patients with type 1 diabetes mellitus and consider ketone monitoring in others at risk for ketoacidosis, as indicated
Common side effects are mild and include injection site reactions (redness, irritation), temporary water retention, tingling or numbness in the extremities, mild headache, and occasional flushing
Then push the plunger up just enough to expel the air
Looking and feeling great afterward is the other part
Vishal Uppal, Associate Editor, Canadian Journal of Anesthesia/Journal canadien danesthsie