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That said, the rate of decline varies considerably from person to person, some women maintain good egg quality into their late 30s, while others experience earlier decline due to genetics, lifestyle factors, or conditions like endometriosis or premature ovarian insufficiency

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doi: 10.1016/j.mrrev.2014.11.002 60 BirbenESahinerUMSackesenCErzurumSKalayciO

doi: 10.1023/a:1015899003974

The typical experimental strategy is the detection of the parent compound excreted unconjugated in urine

The presence of targeting ligands resulted in two-fold higher uptake of nanocarriers in the control healthy (2.09 ng/g protein) and PD organoids (1.85 ng/g protein) compared to uptake of the non-targeted nanocarriers in the control (1.01 ng/g protein) and PD (0.92 ng/g protein) organoids (Fig