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Cell Reports Medicine
Berg AH, Combs TP, Scherer PE
Foods cannot replace GLP-1 medications
In practice, most clinicians would likely taper tirzepatide down before initiating retatrutide to manage overlapping GI side effects and assess the new compound's individual response
In June 2025, Amgen announced positive Phase 2 trial results for MariTide showing up to ~20% weight loss in obese patients and ~17% in type 2 diabetes patients, presented at the ADA 85th scientific sessions
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