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Glutathione Depletion Accelerates Cigarette Smoke-Induced Inflammation and Airspace Enlargement

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This is because, within the cell, NAD + is at high concentrations and NADH is at low concentrations

This activation involves phosphorylation and nuclear accumulation of TAp63 in oocytes, which subsequently triggers the expression of pro-apoptotic Bcl-2 family members, including PUMA, NOXA, and Bax, initiating the apoptotic pathway (Suh et al., 2006

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GSTs can constitute up to 10% of cytosolic protein in some mammalian organs