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KEY FINDINGS Average weight loss on treatment: 7.9 kg (all GLP-1s) 16.1 kg (newer GLP-1s like semaglutide/tirzepatide) Weight regained after stopping: 0.70.8 kg/month 8.39.6 kg regained in the first year Full return to baseline: 0.9 years (older GLP-1s) 1.7 years (newer GLP-1s) Bottom line: GLP-1s are effective, but without ongoing treatment or structured long-term care, the benefits fade quickly
PMID: 14988249
After initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)
The addition of KPV provides insurance against inflammatory damage while youre rebuilding yourself from the ground up
Proximal duodenal uptake of [ 68 Ga]Ga-NOTA-MAL-Cys 39 -exendin-4 was significantly increased after DSS induction compared with controls
If cholesterol hypersecretion occurs, the gallbladder bile will become consistently supersaturated with cholesterol [23], a potent condition predisposing to precipitation and aggregation of cholesterol crystals [24]
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