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Where It Acts The primary target cells are dermal fibroblasts (the cells responsible for producing collagen, elastin, and the extracellular matrix proteins that give skin its mechanical structure) and basal keratinocytes (the proliferating cell population at the bottom of the epidermis)
Patients taking Rybelsus who develop a rash should not automatically assume it is caused by the medication, as skin reactions can arise from numerous causes including concurrent medications, underlying health conditions, allergies to other substances, or unrelated dermatological conditions
Why Dosing Strategy Makes a Big Difference Both medications start at low doses to minimize side effects such as nausea or bloating
Paley CA, Johnson MI
The experimental environment is set at a temperature of 20C and a relative humidity of 60% 80%
However, as previously mentioned, genetic mutations are often inactive until an environmental stressor impacts the expression of the gene
