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Researchers may also evaluate treatment duration, dosing schedules and safety outcomes

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For pharmaceutical injury cases, many states apply a "discovery rule," meaning the clock starts when you discovered (or reasonably should have discovered) that the medication caused your injury, not necessarily when the injury first occurred

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Most notably, it was shown that ROS are not only incidental side-products of metabolism but also generated by systems that have evolved to do so in a programmed manner (Doke 1985