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5 Novel targeted drugs Advancements in understanding the pathophysiological mechanisms of DN have led to the development of novel targeted therapies aimed at specific molecular pathways involved in nerve damage and pain transmission (Table 1 and Fig

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Post-Exertional Malaise (PEM) and Severe Fatigue: By protecting mitochondrial membranes from lipid peroxidation and supporting efficient ATP production, glutathione helps restore cellular energy reserves, potentially reducing the severity and duration of exertion-induced crashes

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