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This 16 to 20 week titration period exists specifically to allow the body to adapt at each dose level before increasing

Clinical practice guidelines[20, 21] have recommended the use of SGLT2i in individuals at higher risk of HF, while GLP-1RA may be prioritized in those with T2DM at higher ASCVD risk (calculated 10-year ASCVD risk 10%, Class IIa, level of evidence: B) given their neutral effect on HF hospitalization [22]

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