Enns, GM, Cowan, TM 2017, Glutathione as a Redox Biomarker in Mitochondrial Disease Implications for Therapy, Journal of Clinical Medicine , vol
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Excessive pro-inflammatory cytokines suppress the negative feedback of the HPA axis, boost the permeability of the blood-brain barrier, decrease the synthesis of neurotransmitters such as serotonin (5-HT), and ultimately lead to the onset of depression (Haroon and Miller, 2017
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These alterations are compatible with an activation response of microglia