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Research has investigated it primarily in sleep-architecture, stress-axis, and neuroprotection models, though its mechanism of action remains unresolved (PMID 16539679)

However, long-term safety data remains sparse, and individual tolerability depends on injection-site reactions, baseline metabolic health, and concurrent medication interactions

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Additionally, serine/threonine kinase 40 (STK40) functions as a COP1 adaptor and promotes the assembly of c-Jun and COP1 complexes 32

Until recently they have had little support from the two dominant GLP-1 drug makers, Novo Nordisk and Eli Lilly who have not considered addition a high prioroty (Sheridan)