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Clinical trials have not identified heart failure as a significant adverse event, and the SUSTAIN-6 trial demonstrated cardiovascular benefits rather than harm

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Spironolactone (40 mg/kg, daily, 8 weeks, i.g.) reduces urinary albumin excretion, blood lipids and fasting blood glucose levels, alleviates renal damage, promotes autophagy and reduces podocyte loss [10]

For this study, 2 ml of blood was taken from the antecubital venous vein and added to a biochemistry tube

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