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The authors proposed peripheral mechanisms such as reduced genital blood flow and central modulation of dopamine and noradrenaline in brain regions regulating reward and arousal

Serious adverse effects , though rare, can include pancreatitis, gallbladder problems, and kidney complications

Gout There are some limited studies in patients with gout, some reporting a possible flare of gout when therapy with GLP1 is started, mostly due to rapid weight loss and dehydration that may precipitate gout attacks

Association between osteoarthritis and dyslipidaemia: A systematic literature review and meta-analysis