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When the medication is discontinued, those appetite signals can return
Tummino, PhD, Nimbus president of research and development, stated at the time
However, CIs for many sensitivity analyses crossed the null (OR = 1), particularly in MR-Egger, which is known to have lower statistical power due to its reliance on stronger assumptions (e.g., Instrument Strength Independent of Direct Effect)
it actively produces oestrogen through the conversion of androgens via the enzyme aromatase
Taking things slower can lower this risk
Many patients follow an initial protocol over a few months, then reassess to decide whether to continue, adjust, or transition into a lighter maintenance plan
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