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Irritating a nerve Injected in the wrong spot, a needle can come close to a nerve and cause sharp pain, tingling, numbness or weakness

Reduced lipogenesis is among the better-supported mechanistic features

This is more modest than GLP-1 agonists but tends to be more sustainable with less muscle loss

Tesofensine side effects can include dry mouth, difficulty sleeping, anxious feelings, increased blood pressure, and serotonin syndrome (if combined with antidepressant medication.) Who should NOT use Tesofensine

Gastrointestinal symptoms Tongue soreness, appetite loss, and constipation have also been associated with vitamin B 12 deficiency

Women of childbearing age should use contraception while on tirzepatide and discontinue the medication at least 2 months before attempting conception to allow complete washout given the long half-life