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While many of these molecules showed promising results in preclinical rodent, minipig, or non-human primate (NHP) models, they could not achieve sufficient therapeutic windows to observe clinical weight loss without adverse events such as cardiac activation ( MK-0493 MK-0493 is an orally available small molecule developed by Merck ( Figure 2 )

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Some participants also reported stomach discomfort, reduced appetite, fatigue, headache, dizziness, or injection-site reactions

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A prospective study to evaluate the efficacy and safety of vitamin E and levocarnitine prophylaxis against doxorubicin-induced cardiotoxicity in adult breast cancer patients