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The FDA approved once-daily oral semaglutide (Wegovy) at 25 mg on 22 December 2025, making it the first oral GLP-1 approved specifically for chronic weight management in the US
Threshold for GLP-1R-positvity was established using flow cytometry read outs from the PANC-1 cell line ( Supplementary Figure 1 )
The science is biologically plausible, the early findings are encouraging, and the available safety data appears favorable, but its important to be transparent about what we know, what we dont know, and where the evidence still needs to mature
