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PMID 26951899
This conservative approach allows for assessment of individual tolerance before increasing to the 2-5mg range used in more intensive protocols
Busulfan, fludarabine, and cyclophosphamide (BFC) conditioning allowed stable engraftment after haplo-identical allogeneic stem cell transplantation in children with adrenoleukodystrophy and mucopolysaccharidosis
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Cystine is then imported into the cell via system Xc , where the SLC7A11 subunit plays a critical role in maintaining redox homeostasis due to its specificity for transporting cystine and glutamate and SLC3A2 acts as a molecular chaperone that stabilizes SLC7A11 at the plasma membrane
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