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However, as their use has skyrocketed, emerging research suggests that some individuals may be at risk for unexpected complications, including serious vision problems

When the combination of sitagliptin and metformin immediate-release was coadministered with a sulfonylurea or with insulin, the percentage of patients reporting at least one adverse reaction of hypoglycemia was higher than that observed with placebo and metformin immediate-release coadministered with a sulfonylurea or with insulin (Table 3)

Received: 08 February 2024 | Accepted: 20 March 2024 | Published: 29 March 2024 Keywords: antioxidant systems

Large randomized trials, including the SUSTAIN and SELECT studies, tracked cardiovascular events across thousands of patients

The drug is metabolized via proteolytic cleavage and beta-oxidation of the fatty acid side chain, with metabolites excreted primarily in urine and feces

12.3 Pharmacokinetics Sitagliptin The pharmacokinetics of sitagliptin have been extensively characterized in healthy subjects and patients with type 2 diabetes mellitus