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The $50 billion elephant in the room is whether there will be enforcement by the FDA against compounders alleging violations of the FDCA prohibition on compounding products that are essentially a copy of FDA-approved products now that the branded GLP-1 products are no longer in shortage

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GLP-1RAs have the potential to inhibit cardiac inflammation via retarding the production of pyroptotic cytokines, caspase-1 and the AMPK-thioredoxin interacting protein (TXNIP) pathway in high-fat diet-fed rats [80]

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