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It appears to represent a recalibration of the brain's reward and satiety circuitry, reducing the hedonic drive to eat independently of hunger signals

Diabetes-related complications : Long-term health problems caused by uncontrolled diabetes, including nerve damage, kidney disease, and heart issues

Because pigment loss changes the structure of the hair shaft, grey hair is often coarser or wirier due to keratin changes

Treatment should not be delayed if neurological symptoms occur, as nerve damage may become irreversible without prompt B12 replacement

Mawardi HH et al

These effects were especially noticeable in older animals, not young ones, and occurred even without significant weight loss