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224 Various enzymes released by NETs and TANs facilitate ECM remodeling, underscoring neutrophils role as contributors to tumor pathology

53,54 This distinction is conceptually important because it shifts the emphasis from ROS diffusion to self-propagating redox state transitions

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The First-Pass Problem: What Happens in the Liver First-pass metabolism refers to the phenomenon where orally administered compounds are absorbed through the intestinal wall, enter the hepatic portal vein, and are metabolised by liver enzymes before reaching systemic circulation