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For hair and skin, the evidence includes topical skin trials, wound studies, mouse hair-follicle data, and related copper-peptide hair follicle models rather than large, modern randomized trials for hair loss [2], [3], [6], [13]

On the other hand, the concept of non-genomic or cytoplasmic response was introduced in 1967, when Szego and Davis observed an increase in cyclic adenosine monophosphate (cAMP) in the MCF-7 breast cancer cell line pretreated with estrogens (Szego and Davis, 1967)