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Research evidence The pivotal efficacy evidence comes from two identically designed Phase 3 randomized placebo-controlled trials run by Theratechnologies and reported by Julian Falutz and colleagues in the New England Journal of Medicine in 2007 (Falutz et al., NEJM 357:2359-2370)

Milk thistle (Silybum marianum) is a Mediterranean plant whose seeds contain silymarin, a group of antioxidant plant compounds

Scientific interest grew because laboratory investigations suggested Body Protection Compound-157 influences several biological processes associated with tissue repair and cellular recovery

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Clinical trial protocols from the Phase 2 NEJM study used a gradual escalation approach, starting at low doses and increasing every four weeks