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Glutathione peroxidase (GPX) role in oxidative stress and its interaction with superoxide dismutase (SOD) The SOD gene locus resides on chromosome 21 and as a consequence of gene dosage excess, SOD activity has been shown to be increased by about 50% in all tissues of patients with Down syndrome (Brooksbank & Balzas, 1983

Above all, as with all MR studies, pleiotropy effects in the MR setting are challenging ( 5 Conclusion In conclusion, we provided evidence that genetically proxied GLP-1RAs were associated with a reduced risk of ED, and to a lesser extent, T2D, obesity, hypertension and CVD mediated this effect