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Sample size was computed on the basis of pilot data and previously published data

Common semaglutide side effects (nausea, vomiting, constipation) and bupropion effects (dry mouth, insomnia, mild blood pressure elevation) may overlap or feel amplified early in treatment

According to the NHS, adults aged 19 to 64 years need about 1.5 micrograms of vitamin B12 a day

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