References View all references + Sikiri, P., et al
The oral form uses a SNAC (sodium N-[8-(2-hydroxybenzoyl)amino]caprylate) absorption enhancer to allow GLP-1 passage through the gastric mucosa, achieving approximately 1% bioavailability compared to subcutaneous injection
The main consideration during this phase is maintaining adequate nutrition despite continued appetite suppression
However, ongoing research, such as the FLOW trial, which had been comparing GLP-1RAs to a placebo in patients with T2D and CKD, was recently halted prematurely due to their effectiveness
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