Ovarian cancer is the sixth most common malignancy among women in developed countries and the fifth leading cause of cancer-related death, representing a complex disease associated with poor survival rates.24 The combination chemotherapy of Paclitaxel (PTX) and Carboplatin (CARB) is considered the first-line treatment regimen for ovarian cancer.25 Both agents play distinct roles in inhibiting the growth of ovarian cancer through different mechanisms,26 and they are known to exert a synergistic anti-tumor effect by activating separate apoptotic signaling pathways, thereby potentially reducing drug resistance.25 The gonadotoxic effects of platinum-based chemotherapeutic agents have been demonstrated in numerous studies, both histopathologically and in terms of follicular development.27-29 In the present study, CARB administration led to significant histopathological damage in ovarian tissue, including follicular degeneration, prominent stromal edema, congestion, hemorrhage, inflammation, and fibrosis, particularly in the medullary region
Most are shipped as a lyophilized (freeze-dried) powder, which is the most stable form for long-term storage
Titration of GRX1-roGFP2 and roGFP2 was done with DTT, which has a more negative reduction potential than lipoic acid ( E DTT = 323 mV, Shaked et al., 1980)
The compound remains in research status, lacking the clinical trial data required for regulatory approval
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Glutathione peroxidase catalyzes the reduction of hydrogen peroxide and lipid peroxides into water and hydroxyl lipids, respectively, along with the oxidation of glutathione (reduced-form) into glutathione disulfide
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