They are typically involved in various physiological functions, including the regulation of metabolism, immune response, and inflammation
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showed that, acidic extracellular microenvironment enhances the invasiveness of prostate cancer PC-3 cells by upregulating the secretion of cathepsin B, a protease involved in extracellular matrix degradation (75)
Using preclinical models of breast cancer, the team also found they could slow tumor growth by blocking the cancers ability to use glutathione
#6 This may be a bit hardcore
Overall, CagA mediates cellular ferroptosis through its influence on iron and ROS content, lipid oxidation, and GPX4 activity