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Herein, we provide a systematic and complete review of all integrin family members and integrin-mediated downstream signal transduction to highlight ongoing efforts to develop new therapies/diagnoses from bench to clinic

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In addition, studies have shown GLP-1 expression in cells increases with T2D development, suggesting they play an integral role in the attempt to regain normoglycemia 22, 23, 26, 27

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The protein thioredoxin, together with TXNRD1 (or TXNRD3), NADPH, and FAD, constitute the thioredoxin antioxidant system involved in the reduction of antioxidant enzymes (e.g., peroxiredoxins, methionine sulfoxide reductases, and ribonucleotide reductase) and of many oxidation/reduction (redox)-sensitive signaling proteins (9)

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