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The ChEMBL drug registry records tirzepatide at maximum phase 4 (approved), first approval 2022, parenteral, with a first-in-class GIP-agonist designation and a boxed-warning flag
The peptide stimulates angiogenic pathways, stabilizes vascular walls, accelerates cellular migration, and reduces local inflammation
Drmic et al., Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME, World J
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