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Within the ER, hexose-6-phosphate dehydrogenase converts glucose-6-phosphate and NADP + to 6-phosphogluconate and NADPH in a single step, whereas this process in the cytosol requires two separate enzymes (G6PD and PGLS)

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doi:10.1111/crj.12915 Gharsalli H, Oueslati I, Sahnoun I, et al

Lun W, Yan Q, Guo X, Zhou M, Bai Y, He J, et al