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Acute inflammation is essential for initiating the healing process, clearing damaged tissue, and recruiting repair cells to injury sites

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The activity of eNOS is tightly regulated by multiple intracellular process including posttranslational modification, phosphorylation and proteinprotein interactions 14,15

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It stimulates the release of growth hormone from the pituitary gland, which can have various effects on the body, including increasing muscle mass, reducing fat mass, and improving recovery from injuries

Research has shown that weekly injections at higher doses may promote fracture healing to a similar extent as daily lower-dose injections in rodent models, though human verification of weekly protocols is still in progress