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Lancet 398 , 759771 (2021)
It should be injected subcutaneously into the abdomen, thigh or upper arm
If you find that morning injections make you nauseous, it is perfectly safe to switch to evening injections for your next dose
You should have regular follow-ups with your provider to review progress, symptoms, lab insights, and lifestyle shifts
The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%
doi: 10.1371/journal.pbio.2004248 72 ReichK
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