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Ethics statement All experimental procedures were approved by the Ethical Committee of the Faculty of Veterinary Medicine of the University of Ghent, Belgium (approval number EC2011-113) and carried out in accordance with the approved guidelines and regulations

In patients with asthma, melatonin secretion is frequently dysregulated and has been associated with nocturnal symptom worsening (15)

For example, it is possible that the convenience of a once-weekly medication, in contrast to a basal-bolus insulin regimen, which is intensive and requires regular blood glucose monitoring and multiple injections, may have contributed to the relative improvement in HRQoL

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Barrier dysfunction increases epithelial permeability, enabling inflammatory cytokines to penetrate deeper tissues and exacerbate intraepithelial damage