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It binds the GHRH receptor (GHRHR) on somatotroph cells of the anterior pituitary, activating adenylyl cyclase, raising intracellular cAMP, and triggering pulsatile growth hormone secretion

Oxidative stress and neuroinflammation create a reciprocal pathological process that facilitates redox imbalance and contributes to immune dysregulation in the central nervous system (CNS)

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Lean individuals stopping these drugs may experience weight gain beyond their pre-treatment baseline, creating a cycle of repeated treatment dependency

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While weight loss is the intended outcome of Wegovy, unintended or excessive weight loss can lead to nutritional deficiencies, fatigue, and muscle loss