This is expected with any GLP-1 medication and usually improves as the body adapts
The selectivity of Ipamorelin is clinically significant
Zangerolamo L, Vettorazzi JF, Rosa LR, Carneiro EM, Barbosa HC
In LPS-activated macrophages, the expression of Phosphorylated Phosphatidylinositol 3-Kinase (p-PI3K) and Phosphorylated Mammalian Target of Rapamycin (p-mTOR) increases (Xue et al., 2017
People with obesity dont just have elevated adiposity, they also have elevated muscle mass and lean tissue mass overall, explained Kevin Hall, a researcher at the National Institute of Diabetes and Digestive and Kidney Diseases, on a Ground Truths podcast in November
It deliberately doesn't name a weight threshold or BMI requirement on the homepage - the clinical determination happens during the intake review