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This is where synthetic modifications like IGF-1 LR3 and IGF-1 DES come into play
10.1016/j.orcp.2015.08.016 40 MaE.WoD.ChenJ.YanH.ZhouX.HeJ.et al (2023)
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RNA was isolated from liver and cell samples using TRIzol reagent (Life Technologies, Thermo Fisher Scientific, Waltham, MA, United States) and converted to cDNA using a reverse transcription kit from Thermo Fisher Scientific
Side effects tend to mirror those of GLP-1 agonists: Nausea Diarrhea Decreased appetite Possible gallbladder effects (as with all rapid weight loss) Minimal risk of hypoglycemia when used without insulin Importantly, GIP on its own does not cause hypoglycemia , making it a relatively safe therapeutic target
Convenience / Administration: Convenience / Administration: Oral therapies offer some promise as a more convenient option than the leading injectables
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