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A Tiny Peptide With an Outsized Effect As expected, GLP-1 strongly activated the neuronal cells, increasing their activity to three times the level seen in untreated control cells

The most useful nuance for readers comparing headlines: REDEFINE 1's 20.4% number is the treatment-policy estimand (closer to intention-to-treat what happens regardless of whether participants stayed on treatment)

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What they have is decades of behavioral and physiological data showing it does something sleep modulation, stress response regulation, pain attenuation, opioid withdrawal effects across multiple species

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In addition, high levels of B12 and NAD have been correlated with longer telomeres, specialized proteins at the ends of linear chromosomes